By Ronald R. Watson
The 1st connection with acquire the most recent learn and studies at the remedy and pathogenesis of center illness in AIDS sufferers, this reference makes an attempt to enhance the analysis, administration, and treatment of HIV-associated center failure by means of learning the lengthy results of immunosuppression and opportunistic and viral an infection, in addition to cofactors affecting middle ailment similar to drug-related cardiotoxicity, cocaine abuse, and dietary deficiencies on cardiac functionality.
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We examined the effects of tat protein on endothelial cell signaling and cytokine secretion. Human pulmonary endothelial cells were activated with either tat protein (100 to 250 ng/mL) or IL-1 β (10 ng/mL) for varying periods of time. Cytoplasmic and nuclear membrane protein was isolated and assayed for p38 MAPK by Western blotting and for NF-κB nuclear translocation by electrophoresis mobility shift assay. Supernatants of stimulated cells were collected after 24 hr and assayed for cytokines by enzyme-linked immunosorbent assay (ELISA).
BFGF is a true angiogenic factor, which is also required for growth and maintenance of KS. The RGD sequence of tat is also able to induce the expression of a 72-kDa collagenase, a metalloproteinase that is important for mediating the invasive properties of KS. EFFECTS OF GP120 PROTEIN ON ENDOTHELIUM The envelope glycoprotein gp120 has several effects relevant to endothelial cell function, some of which could predispose the blood vessel to atherogenesis. Gp120 has been shown to alter endothelial permeability and to induce endothelial cell apoptosis.
James TN. Normal and abnormal consequences of apoptosis in the human heart (review). Annu Rev Physiol 1998; 60:309–325. 107. Marschang P, Gurtler L, Totsch M, Thielens NM, Arlaud GJ, Hittmair A, Katinger H, Dierich MP. HIV-1 and HIV-2 isolates differ in their ability to activate the complement system on the surface of infected cells. AIDS 1993; 7(7):903–910. A. A. A. INTRODUCTION HIV-1 cardiomyopathy (HIVCM) is an increasing cause of cardiovascular morbidity and mortality in young and middle-aged HIV-1-positive adults surviving acute complications of AIDS (1,2).