By F.J. Dixon, Henry G. Kunkel (Eds.)
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Extra resources for Advances in Immunology, Vol. 16
NATVIG AND H. G. KUNKEL 22 SPECIFIC TABLE XI AMINOACIDS RELATICD TO GICNiscTic ANTIGENS Antigens Chain Gm a Non-a 74 non-a Gm f Gm s Gm 4a Gm 4b G~rtg Yon-g Gm bo Non-bo yl-2-3 y4 FC InV (1) InV (2) OZ+ Oz - Yl a 71-2-3 Y4 Yl Yl Y4 74 r3 72-3 73 ~l-2-3 ~l-2-3 Y4 K K x x Subfragment and homology region pFc' CH3 pFc' CH3 pFc' CH3 Fd CH1 Fd CHI Fc CH2 Fc CH2 Fc CH2 Fc CH2 pFc' CH3 pFc' CH3 pFc' CH3 pFc'CH3 Ck Ck CAI CX2 Sequence NO. Amino acids 355-358 355-358 Arga Asp. Glu Leua Arga Glua Glu Met" 355-358 Glna Glua Glu Mete 214 214 309 309 296 296 436b 436 445 445 191 191 190 190 Arga LYS" Val Leu His Val - His Tyra Phea Phee Tyr" Pro" Leua Leua VaP Lysa Arga Can be explained by point mutation.
B. Order of Heauy-Chain Cistrons. The most likely interpretation of the Lepore type of IgG is a deletion type of hybridization. Since the N-terminal part of the molecule is y 3 and the C-terminal is 71, this can only be explained by having the 73 cistron to the “N-terminal” side of 71. Also, since there is no deletion of y2 and y4 and other classes in this instance, y l and y 3 are likely to be adjacent. This is also compatible with gene complexes in the population groups which are easily explained by this order.
There are two observations supporting the contention that lymphocytes may contain Ig genetic markers that are not present in the respective serums. 1. , 1970b). 2. The fluorescent antibody technique was used in another study where also evidence was obtained for genetic markers of lyniphocytes that were not present in the respective serum (Curtain and Baumgarten, HUMAN IMMUNOGLOBULINS 31 1965; Lobb, 1968). However, this was performed with heteroantisera which require very strong absorptions, particularly for genetic markers belonging to minor subclasses such as G m ( b ) and G m ( g ) of IgG3.